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Allow 2-4 weeks to assess tolerance before increasing

Goodman & Gilman's The pharmacological basis of therapeutics (10th ed.)

Its impact is more or less pronounced, depending on how much you drink, how quickly your liver can process it, and other factors, such as your sex and body weight

intracellular half-life is prolonged because of lysosomal release and cytosolic resequestration, creating a depot effect that supports monthly maintenance dosing for chronic deficiencies

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