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Initially, rats were placed in operant conditioning chambers and allowed to lever-press for intravenous infusions of cocaine (0.245 mg/kg/infusion, infused over 5 s) on a fixed-ratio 1 (FR1) schedule of reinforcement similar to our previous studies 8,14,18,22
Two researchers independently evaluated studies to determine their suitability for inclusion
Tirzepatide represents a dual agonist, activating both GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) receptors, which may explain its particularly robust weight loss effects
It also boosts the livers ability to regenerate by stimulating protein synthesis, which helps repair damaged liver tissue
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