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To view or add a comment, sign in Figure 2 from this recent genetic cardiomyopathy paper is wild Patients with type 2 diabetes who carry a pathogenic cardiomyopathy variant had a 16% rate of heart failure hospitalization at 4 years on placebo, approx 5 higher than noncarriers

Ozempic, Wegovy, Mounjaro, and similar medications cause significant fat mobilization through both caloric restriction and metabolic changes

Journal of Biological Chemistry, 268 (4), 25712576

These convergent effects support the hypothesis that multi-incretin agonists may exert central benefits beyond metabolic regulation

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Factors accelerating tolerance include consistent calorie restriction without adequate protein, insufficient water intake, sedentary behavior, and rapid dose escalation followed by long plateaus at a single dose