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Why Weight Loss Plateaus on Semaglutide or Tirzepatide and What to Do About It Joshua Silva, MD Dec 16, 2025 6 min read Updated: Jan 15 Medically authored by Joshua Silva, MD | Evidence-Based Weight Loss at Potere Health MD Last clinically updated: December 2025 Many people taking semaglutide or tirzepatide notice that weight loss is faster at first and then slows or pauses over time

This arrangement would produce savings for individuals who take drugs with high rebates, since they would face lower out-of-pocket costs on their medications when they fill their prescriptions

Wegovy is FDA-approved for chronic weight management and cardiovascular risk reductionnot diabetes

It does not work if men do not achieve or maintain an erection, but the effect still helps with overall sexual function

Understanding these pathways can inform provider discussions about titration speed and dose-adjustment expectations

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