There are few randomized controlled trials (RCTs) directly comparing subcutaneous tirzepatide with subcutaneous semaglutide
Semaglutide demonstrated approximately 15% weight loss in clinical trials, which represented a major improvement over previously available weight management medications
Researchers found that, compared to placebo, the highest dosage of tirzepatide (15 mg given once weekly) was most effective in reducing HbA1c (mean difference of 2%)
Additionally, if you have a history of thyroid cancer or medullary thyroid carcinoma in your family, discuss this with your provider before starting any GLP-1 medication
Ditano-Vzquez P, Torres-Pea JD, Galeano-Valle F, Prez-Caballero AI, Demelo-Rodrguez P, Lopez-Miranda J et al (2019) The Fluid Aspect of the Mediterranean Diet in the Prevention and Management of Cardiovascular Disease and Diabetes: The Role of Polyphenol Content in Moderate Consumption of Wine and Olive Oil
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