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It is naturally produced in the liver and plays a crucial role in protecting our cells from oxidative stress and inflammation

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Monitoring Schedule Serum IGF-1 at baseline and at 8-12 weeks Fasting glucose at baseline and every 3-6 months (GH increases insulin resistance acutely) Thyroid panel at baseline (hypothyroidism blunts IGF-1 response) Blood pressure and fluid retention assessment at each visit The American Association of Clinical Endocrinology (AACE) recommends IGF-1 be kept within the age- and sex-adjusted reference range during any GH-stimulating therapy to minimize risk of adverse effects including fluid retention and glucose intolerance [9]

Here the mitochondrial matrix is drawn as the top area

Relative gene expression was calculated after normalization to a house-keeping gene (mouse or human 18S rRNA)