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10.1021/acs.jafc.4c08986 54 YangW.CongY
NADPH is also utilized by many oxidoreductases involved in detoxification reactions within the body
The amino acid substitution at position 8 makes semaglutide less susceptible to degradation by DPP-4
Bile (cholestasis) (Figures 2325): Appears as elongated pale green-brown plugs within bile caniculi
RECOMENDACIONES: Precauciones de uso: No se recomienda la administracin de dosis altas durante periodos largos en pacientes con disfuncin renal grave 0 enfermedad renal en fase terminal y sometidos a dilisis, ya que puede producirse una acumulacin en la sangre de los principales metabolitos potencialmente txicos, como son trimetilamina (TMA) y trimetilamina N-xido (TMAO), ya que son excretados en orina normalmente
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