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Retatrutide is a triple agonist, targeting the receptors of 3 hormones that can impact appetite, weight, and blood sugar levels, earning it the nicknames the triple-G and the Godzilla of weight loss jabs

and (3) early oxyntomodulin analogs, which were discontinued in part because regulatory endpoints for combination receptor agonism had not yet been established (Weyer et al., 2001

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