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Important safety considerations include a boxed warning for medullary thyroid carcinoma (MTC) risk with most GLP-1 medications, which are contraindicated in patients with a personal or family history of MTC or Multiple Endocrine Neoplasia syndrome type 2 (MEN2)

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Some people may have unpredictable bleeding, especially at first, but for many, periods become lighter or go away altogether (16)

Zepbound (tirzepatide), a dual GIP/GLP-1 agonist, targets two hormones to boost weight loss outcomes further

The peptide addresses cellular repair mechanisms while physical therapy addresses the motor control and strength deficits that contribute to re-injury risk

Internationally, Novo announced a $1.1B investment in Brazil to expand production and launched Wegovy in China (Nov 2024) and India (Jun 2025)