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doi: 10.1155/2021/9968907 40 LiSXieFShiKWangJCaoYLiY

Upon oral administration of actitretin an inter-patient variability was observed in the pharmacokinetics of the drug

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Further support for these findings comes from transcriptome and gene array analyses of liver tissue from dogs with hepatitis and age-related hepatic changes, which suggest the enhanced expression of genes related to OS and inflammation in hepatic dysfunction [95,99]