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Covers: biochemistry of amylin, receptor biology (CTR + RAMP complex), physiological functions, clinical applications, the Pramlintide experience, perspectives for long-acting analogs

Tirzepatide is the older, fully matured story: a single-molecule dual incretin agonist taken from discovery through Phase 1 proof-of-concept, [7] then through the large SURPASS (diabetes) and SURMOUNT (obesity) Phase 3 programs, and finally to FDA and EMA approval

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