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Each participant in the GLP-1 group was matched 5:1 with participants who had similar characteristics but had not taken GLP-1 medications

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The critical need for mitochondrial GSH in iron-sulfur clusters is consistent with its role as a cofactor for mitochondrial glutaredoxins (Grxs), which are conserved oxidoreductases for ironsulfur cluster biogenesis

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"Although our findings need to be corroborated in other studies, clinicians and patients should be aware of a possible adverse effect of GLP-1 [drugs] on GERD," researchers noted