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As reported by the American Journal of Managed Care, the approval of an oral semaglutide formulation marked the beginning of what many are calling the oral GLP-1 era. In December 2025, the FDA approved the Wegovy (semaglutide) tablet as the first once-daily oral GLP-1 receptor agonist indicated for chronic weight management in adults with obesity or overweight

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Clinical trials have generally started participants on a 2 mg once-weekly retatrutide dosage, with doses increasing at approximately four-week intervals until the planned maintenance dose is reached

131,132,133 Additionally, GLP-1 helps to delay gastric emptying and suppress appetite, aiding in weight management