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Animal studies In rats undergoing laparotomy and intestinal manipulation intravenous administration of ipamorelin in a dose ranging from 0.014 to 0.14 mol/kg resulted in significant acceleration of gastric emptying compared to vehicle-treated animals

This is one reason why the standard protocol involves gradual dose escalation, and it is also why the first week on semaglutide can vary so much from person to person

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14.4.2 Age Restrictions and Clinical Guidelines Adherence to regulatory guidelines is essential