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Lai EC, Felice KJ, Festoff BW, Gawel MJ, Gelinas DF, Kratz R, Murphy MF, Natter HM, Norris FH, Rudnicki SA: Effect of recombinant human insulin-like growth factor-I on progression of ALS

It is now thought to be due to leakiness of the skin barrier, which causes it to dry out and become prone to irritation and inflammation by many environmental factors

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This finding implies a possible link between the activation of the DKK3 subpopulation and the differentiation process leading to myofibroblasts in OA (83)