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Randomized trial of ibrutinib versus ibrutinib plus rituximab (Ib+R) in patients with chronic lymphocytic leukemia (CLL)

Heersche N, et al

Conversely, remaining untreated for obesity during pregnancy carries documented risks: gestational diabetes rates approach 30% in untreated women with obesity, and preeclampsia risk doubles or triples

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More frequent blood glucose monitoringtypically four to seven times dailyis usually necessary during the preconception period, and continuous glucose monitoring may be considered

Additionally, GLP-1 RAs have been demonstrated to activate AP-1, which regulates the expression of apoptotic genes, and to phosphorylate Bad, a pro-apoptotic factor, thereby reducing apoptosis [47] (Fig