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Variability in extraction and quantification methods Another significant challenge is the inconsistent composition of bioactive compounds in Schisandra chinensis extracts, which can vary depending on factors such as geographical location, harvest time and processing methods [1, 9, 100]

143 While some of these agents have demonstrated isolated positive findings, the overall evidence base remains insufficient, with most studies being limited by small sample sizes, methodological variability, or lack of replication

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