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The criteria for liver injury were vacuolization of hepatocytes and pyknotic hepatocyte nuclei, activation of Kupffer cells, and enlargement of sinusoids

The process exhibits a dual role in tumorigenesis by promoting as well as suppressing tumors (167)

PGC-1 regulates DRP1 expression by enriching in the promoter region to downregulate DRP1 expression and further inhibits mitochondrial fission ( via deacetylating and activating OPA1 (Samant et al., 2014)

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Familial Lewy body diseases

Exposure to high doses of H 2 O 2 enhances oxidative stress accompanied by decreases in gene levels of mtDNA-encoded mitochondrial respiratory chain-related proteins such as cytochrome c oxidase subunit 1/2 (Cox1/2), NADPH dehydrogenase subunit 1/4 (ND1/4), and CytB (84)