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Non-drug approaches such as ice packs, heat therapy, rest, and physical therapy are the safest options

The efficacy of these medications has largely been evaluated through small cohort studies and uncontrolled case series, rendering them less recommended for treating muscle cramps comprehensively (25, 28)

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3-5 The absence of oxidants as observed in individuals with a hereditary absence of NADPH oxidase activity leads to excessive inflammation that never fully resolves

Constipation becomes more noticeable for 24% of patients

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