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Previous work had identified ARL8 as an important regulator of axonal transport of lysosomes and synaptic vesicle precursor organelles in human induced pluripotent stem cell-derived neurons (iN) 20

Faster cyclic loess: normalizing RNA arrays via linear models

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Additionally, more compounds make it harder to isolate which one is responsible for any observed benefit (or harm)

Secondary endpoints were safety, side effects, and efficacy

Travica N, Ried K, Sali A, Scholey A, Hudson I, Pipingas A