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The neonatal-onset form of the disease is the more common form of propionic acidemia

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The foundational shift happens here , before anything is visible on the surface

Further complicating the matter, in brewing yeast there exists more complete and less complete versions of the IRC7 gene (long and short versions), differing levels of intact promoter regions (which effectively turn on the gene), and differing allelic profiles (how the gene is carried on different chromosomes) all of these things affect the level of activity of this -lyase enzyme

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