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One model supported by our data proposes that in at least some brain areas, the neuronal response to GLP1R activation is amplified by estrogen

Rahman Z, Kavanagh J, Champlin R, Giles R, Hanania E, Fu S, Zu Z, Mehra R, Holmes F, Kudelka A, Claxton D, Verschraegen C, Gajewski J, Andreeff M , Heimfeld S, Berenson R, Ellerson D, Calvert L, Mechetner E, Holzmayer T, Dayne A, Hamer J, Bachier C, Ostrove J, Deisseroth A, et al

According to the study, the most common adverse effects reported by patients include nausea, vomiting, diarrhea, constipation, and abdominal pain

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doi:10.1200/JCO.2008.16.1547 34

Increasing your dose without medical guidance raises the risk of severe nausea, vomiting, and dehydration