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Therefore, contrary to the traditional approaches, these changes could be explained as the result of ammonium detoxification driven by increased glutamine synthesis from glutamate in astrocytes, without necessarily affecting neurotransmission at late stages of the disease

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Specifically, it stimulates glucose-dependent insulin secretion, decreases glucagon secretion, and inhibits gastric motility and appetite

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1 5 PUVA lentigines are dose-dependent, irregular, small, brownblack macules that are particularly seen on the shoulders, upper back, and limbs (Fig