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When norepinephrine is released in response to cold sensation it binds to -adrenergic receptors on the surface of brown adipocytes triggering the activation of adenylate cyclase

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In the -oxidation pathway, short-chain acyl-CoA dehydrogenase (SCAD, ACADS) catalyzes the oxidative conversion of butyryl-CoA to crotonyl-CoA [53, 54], which serves as the essential substrate for protein crotonylation

Untersttzend wurde eine herabgesetzte Reserpin-Hypothermie (NaBPC157 Vorbehandlung) und eine Umkehr eines weiteren sehr deutlichen Temperaturabfalls (NaBPC157-Nachbehandlung) reproduzierbar festgestellt