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NAD+ levels decrease with age

While very rare, more serious side effects like pancreatitis or gallbladder issues have been reported

GLP-1s can be an important tool in managing this condition

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Surveys show that between 4% and 15% of adults in the US and Western Europe have symptoms consistent with RLS.57 In addition, there is evidence that up to 40% of adult RLS sufferers may have had the onset of symptoms in childhood or adolescence

The same is the case for obesity (likely in part via leptin)