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(2024) identified vitamin D-binding protein (VDBP) within plasma microglia-derived EVs as a potential biomarker for major depressive disorder (MDD), a condition frequently comorbid with cognitive decline, thereby highlighting the utility of EV-associated vitamin D components in detecting and understanding brain disorders [138]

Usually administered for gut and general inflammation

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Consultation with the FDA resulted in a reduction in the studys sample size from 600 to 292 patients based on the measured pooled incidence of the primary endpoint and a re-estimation of the study power