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374 New potential pharmacological targets The abovementioned antidepressants have been utilized as clinical therapies for MDD, but it is difficult to elucidate the exact pharmacological mechanisms of every medicine due to delayed clinical efficacy, poor treatment response to some patients, and difficulty in effectively controlling the incidence of suicide

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Black cohosh has also been found to cause liver damage in some people

Obesity Weight gain and metabolic disorders, including insulin resistance, often go hand-in-hand with thyroid conditions and inflammation