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While significant heterogeneity was noted across the analyses, sensitivity analyses confirmed a consistent direction of effect, reinforcing the class-wide anti-inflammatory properties of GLP-1 RAs

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Four EC subtype clusters were identified based on established markers: capillary endothelial cells ( EGR1 + ), arterial endothelial cells ( EFNB2 + ), venous endothelial cells ( NR2F2 + ), and endocardial endothelial cells ( NRP3 + ) 30,31,32 (Fig