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Additionally, its binding affinity is four times greater than that of native human GLP-1, which supports the formulation of a convenient once-a-day dosage regimen [14, 15]

However, we now know they do much more

The gastrointestinal tract in hunger and satiety signalling

Regardless, our study provides real-world evidence in support of the renal-protective effect of GLP1-RA on kidney function in patients with moderate to advanced CKD, although mechanisms of kidney protection remain to be elucidated