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It follows a circadian rhythm, with its peak occurring 90 to 120 min after the rise in serum bile acid levels following meals [115]

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3 Results 3.1 Study selection and characteristics The initial systematic literature search across PubMed, Embase, and the Cochrane Library yielded 1,148 records

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[128] Studies examining medication stability under high-temperature conditions suggest that while brief exposure to elevated temperatures may not significantly affect the active ingredient, prolonged exposure can potentially alter the tablet matrix and affect drug release characteristics

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