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Discussion A total of more than 1000 papers dealing with the subject were identified in the databases described in the search strategy of this protocol, reinforcing that experimental, epidemiological, and randomized clinical trials involving the association between excess Se and hyperglycemia are increasingly frequent [2124]

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Chrysin upregulates fatty acid transport genes Cd36 and Cpt1b, reduces long-chain fatty acid accumulation, promotes mitochondrial fatty acid oxidation, and simultaneously restores the expression of genes related to mitochondrial oxidative phosphorylation and TCA, increases total adenylate concentration, improves energy production, and ameliorates right ventricular dysfunction in PAH rat models (Kobayashi et al., 2022)

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As part of the Semaglutide Unabated Sustainability in Treatment of Type 2 Diabetes (SUSTAIN) program, the efficacy of once-weekly subcutaneous semaglutide was evaluated in over 7,000 patients in six global phase IIIa trials (SUSTAIN 16) across the wide spectrum of the T2D disease course (1621) and in nearly 3,000 patients in four phase IIIb trials (SUSTAIN 710) (2225) ( Table 1 )

A new era for oral peptides: SNAC and the development of oral semaglutide for the treatment of type 2 diabetes