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Conversely, a few studies reported high levels of vitamin B12 in the blood of patients with a worse COVID-19 outcome 48,49 potentially due to cytolysis leading to the release of intracellular B12 into the plasma and disrupted B12 clearance by the liver, which is often affected in these patients 50

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Glutathione depletion is associated with oxidative stress, inflammation, and impaired mitochondrial function, which can indirectly slow metabolism by reducing ATP production efficiency

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The current outcomes are in line with the report of [64, 65] who revealed that treatment with BV effectively reduces lipid peroxidation and increased values of SOD and GSH in mice bearing solid tumors

Oya M, Matsuoka K, Kubota M, Fujino J, Tei S, Takahata K, et al