According to that notice, early reports suggested that patients taking a GLP-1 like Ozempic may be at a higher risk of aspirating (inhaling) their spit or vomit while under anesthesia because of gastroparesis
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The team made three simultaneous changes to the GLP-1 backbone: a position-8 amino acid substitution to block DPP-4 cleavage, an arginine substitution to prevent fatty-chain attachment at the wrong lysine, and attachment of a C18 fatty diacid chain via a short PEG linker at lysine-26
To mitigate cold-chain failures, they are establishing Obesity Centres of Excellence to educate doctors and patients on proper storage and titration
The EMA and MHRA have reviewed reports of suicidal thoughts with GLP-1 receptor agonists, though causality remains unconfirmed
For severe symptoms or life-threatening reactions, patients should call 999 or go to A&E
