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216,217 Exendin-4 was also demonstrated to increase lysosomal function in another study, whereby autophagosome clearance in a rat model of tacrolimus-induced diabetes was increased, promoting cell survival given that autophagosome accumulation causes intracellular damage

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Current Evidence and Clinical Trial Findings Phase 2 data published in the NEJM (2023) showed dose-dependent body weight reductions with retatrutide over 48 weeks, with gastrointestinal side effects being the most commonly reported

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