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GEP44 was developed based on extensive structureactivity relationship studies and earlier preliminary in vivo studies that demonstrated its greater efficacy at reducing both food intake and body weight compared to the agonist peptide, Ex-4, without triggering gastrointestinal distress (as assessed by kaolin intake and behavioral scoring as a proxy for nausea in rats and direct evidence of emesis in shrews) 16

In summary, we confirmed distinct roles of residues r 1 and r 6 for glutaredoxin catalysis using the non-related enzyme PfGrx

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Based on a subgroup analysis the risk was lower for PE (3.1 vs 3.9) and DVT (4.2 vs 5.0)

References Bray, G

Below are common questions that can help clarify what sets each program apart