This occurs because blood rushes to the splanchnic (gut) vascular bed to aid digestion, exacerbating systemic hypovolemia and forcing the heart to race to maintain blood pressure to the brain
For example, if you have a BMI of 31 in 2022, 100 years ago, it mightve been a 22
The source of the infection may be colorectal, urologic, or cutaneous
10.3389/fendo.2021.721135 [DOI] [PMC free article] [PubMed] [Google Scholar] Zheng J., Xie Y., Ren L., Qi L., Wu L., Pan X., et al
Its unclear how Ozempic is connected to NAION, but it could be because of blood pressure changes, inflammation, rapid blood sugar changes, and other scenarios that impact blood flow to the optic nerve
A therapy that works in a young healthy patient to blunt inflammation might not in an older patient with immunosenescence (where the immune cells might not respond vigorously anyway in fact, boosting their mitochondria might be more needed to avoid immunosuppression)