astrazeneca glp 1 pipeline Bolsters Obesity With Promising Early Data for Candidates GLP-1s & Beyond: Understanding Incretin

Klement RJ, Champ CE

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[9] In the stomach, somatostatin acts directly on the acid-producing parietal cells via a G-protein coupled receptor (which inhibits adenylate cyclase, thus effectively antagonising the stimulatory effect of histamine) to reduce acid secretion

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These inconsistencies pose challenges in comparing studies, establishing definitive doseresponse relationships, and extrapolating results from rigorously characterized preparations used in clinical trials to the heterogeneous products accessible to consumers (569)