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These modifications reduce binding to IGF binding proteins, extending its biological half-life relative to native IGF-1

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There is agreement that the modified OGTT is the preferred diagnostic method (statement 33), and diagnostic parameters for early and late dumping syndrome are well established (statements 3436)

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In addition, other cell types, such as fibroblasts, play important roles in promoting tumor growth and metastasis, providing growth factors and contributing to extracellular matrix remodeling with matrix metalloproteinases [148, 149]

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