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This biphasic response curve, where both microgram and nanogram doses work equally well, is unusual and mechanistically unclear

It exists in two main forms: eumelanin (which is darker, usually brown or black) and pheomelanin (which is lighter, often yellow or red)

This receptor selectivity is the principal reason it is so widely used as a research reagent

(2014) 9:e101223

11 GSH depletion and the subsequent low stores of protein thiol result in both calcium release from intracellular stores and inhibition of calcium extrusion, producing a marked increase in cytosolic calcium concentration, which triggers cytotoxicity

It encourages the skin to function better without forcing rapid turnover