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Adrian Soto-Mota, a physician-scientist who studies metabolic disease, told The Epoch Times in an email

Increasing daily water intake supports cardiovascular stability during caloric restriction, as dehydration amplifies heart rate elevation and dizziness

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This change is considered to result in lower extracellular GABA levels and the disruption of E/I balance toward predominately excitatory transmission, which was observed in another study that employed a rat model of prenatal VPA exposure (111)

The overall cardiometabolic benefit of GLP-1RA rapidly expanded beyond the T2DM population, with the Semaglutide Effects on Cardiovascular Outcomes in People with Overweight or Obesity (SELECT) trial describing MACE reduction in the population with overweight and obesity, even in the absence of T2DM [14]