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To sum up, high-altitude hypoxia resulted in a relatively huge difference from the normal group with respect to a large amount of endogenous substances in the myocardial sample

Furthermore, a deficiency in Zip7 shifts macrophage activation towards an M2 phenotype, as evidenced by increased expression of the M2 marker CD206 and reduced levels of the M1 marker NOS2, along with lower production of proinflammatory cytokines such as TNF- and IL-6

Vitamin C neutralizes oxidative stress caused by fungal toxins, protecting host tissues and it enhances the effect of antifungal drugs by weakening Candidas oxidative stress defenses

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