By improving blood sugar control, semaglutide helps to reduce the risk of complications associated with diabetes, such as heart disease, kidney damage, and nerve damage
The MHRA update also complements the recent consensus statement from anaesthetic and specialist organisations that provides guidance for how the increased risk can be managed safely in the perioperative period. In early January 2025, the Association of Anaesthetists published a multidisciplinary consensus statement on elective peri-operative management of adults taking GLP-1 and dual GIP/GLP-1 RAs, which advised that patients take GLP-1 or dual GIP/GLP-1 RAs as normal, as well as receive a full risk assessment and peri-operative techniques to mitigate risk of pulmonary aspiration during the peri-operative period
Potency accuracy determines whether the active ingredient is delivered at the intended concentration
Practices such as mindfulness meditation, cognitive behavioural therapy (CBT), and relaxation exercises have been shown in studies to reduce perceived stress and may help normalise cortisol patterns
Clinical Implications The modulation of gut hormones by erythritol and xylitol presents a promising avenue for reducing added sugar in food formulation which can be a significant component in dietary strategies aimed at blood sugar and weight management
4c), equivalent to the anti-PCSK9 antibody Ab#2.1 (Supplementary Fig