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Hong G, et al

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Mechanism of Action: How 5-Amino-1MQ Works The 5-amino-1MQ mechanism of action centers on its selective inhibition of the NNMT enzyme, creating a cascade of beneficial metabolic effects

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Although Pac1r / mice exhibit a complex metabolic phenotype, they display significant glucose intolerance and defective insulin secretion after both oral and iv glucose and impaired insulinotropic responses to PACAP, but not VIP, consistent with the importance of endogenous PACAP for control of insulin secretion (115)