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Even when fertilization is achieved, oxidative stress (inflammation)-induced apoptosis (cell death) may result in embryo fragmentation implantation failure insufficient luteal hormonal levels miscarriage impaired placenta development inadequate growth of the uterine lining (necessary for embryo development congenital abnormalities More reproductive condition-specific

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20 In 1953, Leroy Stevens discovered that spontaneous testicular teratomas occurred in approximately 1% of the 129-strain male mice they studied, with no significant age-related variation in frequency

The most common adverse events were transient, mild to moderate gastrointestinal symptoms