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We propose that some melanomas without apparent precursor lesions arise from melanocytes in which the genetic alterations disrupting these barriers already pre-existed before the proliferation-inducing mutation occurred, thereby enabling the neoplasm to skip an evolutionary phase

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PGN has been shown to induce GI lesions, and tumors, and to induce a severe inflammatory response in the GI tract of most laboratory animals

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Figure 2B ), which was treated with stereotactic radiotherapy (SRT