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Reports of adverse effects following acute or acute-on-chronic exposures remain incompletely characterized, and existing literature has not clarified whether new toxicity patterns emerge when these drugs are used primarily for obesity rather than diabetes. For this analysis, researchers tracked years of data from the National Poison Data System, identifying more than 3,000 incidents prior to that 2021 approval and nearly 7,000 incidents after it

Joseph Rizzo from Mass Eye and Ear, who led the July 2024 study, called it in effect, a stroke of the optic nerve. The vision loss is sudden, painless, and in most cases permanent

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PMID 41500720

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