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When NNMT activity is elevated as documented in obese adipose tissue, several cancer types, and aged skeletal muscle intracellular NAD+ availability decreases, SAM availability decreases, and downstream sirtuin activity (particularly SIRT1 and SIRT3) is reduced

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Individuals who qualify for Klinics weight loss programs generally include adults in Sioux Falls with a BMI of 30+, or 27+ with related conditions like hypertension or sleep apnea