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Translating a 50% reduction in healing time from rats to humans requires pharmacokinetic validation that doesn't exist
But they also reveal its ceiling
NAC can promote osteogenic differentiation of PDLSCs and facilitate bone formation on the tension side by reducing the excessive ROS generated by cyclic stress, enabling NAC to potentially improve bone remodeling and reduce adverse effects of orthodontics (Xi et al., 2022)
Pycnogenol's dual impact: inducing apoptosis and suppressing migration via vascular endothelial growth factor/fibroblast growth factor signaling pathways in breast cancer cells
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