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The Phase 3 TRIUMPH-4 trial (results published December 2025) showed 28.7% body weight loss at 68 weeks the largest reduction seen in any obesity drug trial to date

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They found that the activity of GPx from Candida intermedia yeasts cultured in medium supplemented with 50 mg Se 4+ /L was on a level of 3.02 mU/mg protein

The EMPA-KIDNEY trial enrolled a larger proportion of participants without diabetes mellitus and included individuals with lower mean eGFR (37.3 mL/min/1.73 m) and median UACR (329 mg/g) compared to DAPA-CKD