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The spore-forming nature of both strains is a relevant safety advantage: they are inherently more stable and survivable than traditional probiotic strains, and they are not associated with the colonization concerns sometimes raised about live Lactobacillus supplementation in immunocompromised individuals

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TB500 is studied as a synthetic analogue of thymosin beta four and is examined for its role in actin binding dynamics cytoskeletal organisation and cellular migration signalling